Cholesterol Levels In Dialysis Patients
In a study of dialysis patients, those with higher cholesterol levels had lower mortality than those with low cholesterol.51 Yet the authors claimed that the inverse association of total cholesterol level with mortality in dialysis patients is likely due to the cholesterol-lowering effect of systemic inflammation and malnutrition, not to a protective effect of high cholesterol concentrations. Keeping an eye on further funding opportunities, the authors concluded: These findings support treatment of hypercholesterolemia in this population.
Mistake : Youre Not Exercising Enough
Diet alone is often not enough. It should be combined with exercise, says Michos. When it comes to exercise, the equation is pretty simple: Being sedentary equals lower levels of HDL, according to the AHA. You can lower both cholesterol and high blood pressure by doing at least 150 minutes of moderate-intensity exercise, such as walking, bicycling, swimming, or even doing yard work, each week.
Myth #: You Could Get Cataracts From Taking Statin Drugs
Truth: Some studies have indicated that there may be a relationship between statin drugs and an increased risk for developing cataracts. However, these investigations have been either conducted in animals or in less-than-rigorous studies.
The best evidence we have comes from high-quality clinical trials in humans, which showed that statin drugs do not increase risk of cataract formation, reports Martin. In fact, some studies even performed eye exams in people over time and showed no difference in eye health between those taking and not taking statins.
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Conditions Treated By Crestor And Lipitor
Crestor and Lipitor are used to reduce cholesterol. Crestor or Lipitor should be used, along with a diet low in saturated fat and cholesterol, when diet alone has not adequately worked to lower cholesterol. Crestor and Lipitor lower total cholesterol, LDL, ApoB, and triglycerides. They also increase HDL cholesterol, the good kind of cholesterol.
Other indications are listed in the chart below. Crestor and Lipitor have not been studied in the treatment of Fredrickson Type I and V dyslipidemias.
How Long Does It Take Cholesterol To Go Down
People who need to use medications such as statins to lower their cholesterol should see their cholesterol levels fall quickly. These medications may work in a matter of weeks, and they generally work to a larger degree than lifestyle changes.
However, because diet affects the levels of cholesterol in the body, doctors commonly recommend that people make changes to their diet and lifestyle in addition to taking medications.
Making simple changes to the diet and lifestyle can help reduce cholesterol. These changes vary depending on how strictly a person adheres to their diet. Other factors, such as exercise and reaching a moderate body weight, also play a role.
Some dietary changes may cause minor reductions in cholesterol in as little as
Cholesterol is a waxy, fatty substance that the liver produces. In the body, cholesterol plays a roll in cell function and the breakdown of some types of fatty acids. The body can create all the cholesterol it needs.
Regularly eating these foods adds more cholesterol to the body and raises the levels of cholesterol in the blood.
Additionally, some fats and oils may stimulate the liver to make more cholesterol, potentially increasing the levels even more.
Dietary and lifestyle changes and medications can all help lower blood cholesterol levels.
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What About Using Red Rice Yeast Or Plant Stanols Instead Of Prescription Drugs To Lower Cholesterol
Many people say they prefer to take natural medicines over prescription drugs. However, just because something is natural doesnt mean that its safe. In the U.S., supplements are not regulated as closely as medicines. Supplements can also interfere in dangerous ways with medications that you already take.
However, red rice yeast extract does contain lovastatin, which is the same chemical that is in Mevacor. In some cases, you and your healthcare provider might agree that you should try the supplement with monitoring.
Plant stanols are another nonprescription choice for lowering cholesterol. Plant stanols work by stopping the body from absorbing cholesterol in the intestines. One brand is CholestOff® capsules, while plant stanols are also available in margarine substitutes like Benecol®.
How to take your cholesterol-lowering medicines
When you are taking medicines, it is important to follow your healthcare providers advice carefully. If you dont take medicines exactly as prescribed, they can harm you. For example, you could unknowingly counteract one medicine by taking it with another one. Medicines can make you feel sick or dizzy if not taken properly.
Taking your medicine
Dont decrease your medicine dosage to save money. You must take the full amount to get the full benefits. If your medicines are too expensive, ask your provider or pharmacist about finding financial assistance. Some companies provide discounts for certain medications.
A note from Cleveland Clinic
How Long Does It Take To Lower Cholesterol
Your cholesterol levels are directly tied to your heart health, which is why its so important to make sure theyre in a healthy range. The Centers for Disease Control and Prevention , reports that 78 million adults in the United States had high levels of low-density lipoprotein , or bad cholesterol, in 2012. The organization also states that people with high LDL cholesterol are at a much higher risk of heart disease.
Dr. Nieca Goldberg, medical director of the Joan H. Tisch Center for Womens Health at the NYU Langone Medical Center, says it can take between three to six months to see lower LDL numbers through just diet and exercise, noting that it takes longer to see changes in women than men.
Read on for more information on how to lower your LDL levels.
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What Special Dietary Instructions Should I Follow
Eat a low-fat, low-cholesterol diet. Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. You can also visit the National Cholesterol Education Program website for additional dietary information at .
Reducing Heart Disease Naturally
One thing that this study does show is that cardiovascular disease is complicated.
The study also brings to light another fact about cholesterol drugs are not the only way to lower your LDL levels.
Most doctors who prescribe statins for high cholesterol will also recommend that patients exercise more and eat healthier foods.
But more hospitals and doctors offices are starting to promote lifestyle changes as a way for patients to reduce their risk of cardiovascular disease and LDL levels using diet and exercise alone.
Often this approach involves a whole food or plant-based diet rich in vegetables, fruits, whole grains, beans, legumes like chickpeas and lentils, healthy fats like those in olive oil and avocado, and dairy alternatives.
For many, this diet will be a challenge to switch to. But there is a growing body of research on its benefits.
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Truths About Statins And High Cholesterol
For every drop of scientific evidence that statins are safe and effective, there is a tidal wave of misinformation. Our patients are concerned about statin side effects theyve heard about from family or friends, or read about on the Internet.Statins are the gold-standard for high cholesterol treatment. Theyre a powerful medication, and theyve been proven to save the lives of many men and women living with or having a high risk of heart attack or stroke.But if statins are so effective, why are some people afraid to take them?As with any medication, there are risks associated with taking statins, but the benefits far outweigh the risks for the vast majority of high-risk patients.In an effort to put statin side effects into context and provide honest, scientific answers about statins and their use, weve put together a list of common questions our patients ask us:
Who Needs To Take Statins
In 2018, experts including the AHA and American College of Cardiology released guidelines recommending that doctors prescribe statins to people in the following four high-risk groups:
- People who have cardiovascular disease
- People with a high LDL cholesterol level
- People who are between 40 and 75 years of age and have type 2 diabetes
- People between 40 and 75 years of age who have at least a 7.5% risk of getting cardiovascular disease in the next 10 years
Statins may also be prescribed for people who have high cholesterol levels as a result of genetics. This inherited condition called familial hypercholesterolemia causes some people to produce too much LDL, or bad, cholesterol. Children with FH may also be prescribed statins.
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Effect On Lomitapide On Lipid And Lipoprotein Levels
The effect of lomitapide on lipid and lipoprotein levels has been studied in patients with Homozygous Familial Hypercholesterolemia. The pivotal study was a 78-week single arm open label study in 29 patients receiving treatment for Homozygous Familial Hypercholesterolemia . Lomitapide was initiated at 5mg per day and was up-titrated to 60mg per day based on tolerability and liver function tests. On an intention to treat basis, LDL-C was decreased by 40% and apolipoprotein B by 39%. In patients who were actually taking lomitapide, LDL-C levels were reduced by 50%. In addition to decreasing LDL-C levels, non-HDL-C levels were decreased by 50%, Lp by 15%, and triglycerides by 45%. Interestingly HDL and apolipoprotein A-I levels were decreased by 12% and 14% respectively in this study. Follow-up revealed that the decrease in LDL-C could be sustained for a prolonged period of time .
The above studies demonstrate that lomitapide decreases LDL-C, non-HDL-C, triglycerides, and Lp levels.
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The Effect Of Rosuvastatin On Cholesterol
Rosuvastatin is one of the most potent statins and is currently widely prescribed. It is therefore important to know how much rosuvastatin lowers cholesterol. We searched for all the trial evidence from trials of three to 12 week duration reporting the effect of rosuvastatin on cholesterol. We found 108 trials involving 19,596 participants. Based on an informal comparison with atorvastatin threefold lower doses of rosuvastatin are needed to lower cholesterol by the same amount. This review cannot be used to assess harms of rosuvastatin, because of the short duration of these trials and the high risk of bias for this outcome adverse effects were only reported in 10 of the 18 trials that could be used to assess harms.
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Bile Acid Binding Resins
For example, the FDA has approved a class of drugs known as bile acid binding resins, which were the first cholesterol drugs before statins. Studies in the 1980s showed that these medications lower heart disease risk. One reason they arent often prescribed is that patients have to take a lot of them compared to statins. Bile acid binding resins come in powder form or require taking up to six pills a day. Also, they can cause gastrointestinal side effects.Weve known since the 1990s that statins benefit patients at high risk for stroke and heart disease. Today, several investigators are researching which complementary medications can be prescribed on top of statins to make them even more beneficial and protective.One of these is a drug called Ezetimibe, which on its own provides a modest reduction in cholesterol. Its also been shown recently to lower heart attack and stroke risk when taken in addition to a statin.
How To Take And Store
Lipitor can be taken with or without food. It is quickly absorbed, reaching its peak concentration in the blood within about two hours. Lipitor starts to lower cholesterol within about two weeks of starting the medication.
Lipitor should always be taken in conjunction with a diet to lower your cholesterol and triglycerides.
Store the tablets at a controlled room temperature that’s ideally 68 to 77 degrees F.
If you miss a dose of Lipitor, take it as soon as you remember. But if it has been more than 12 hours since the missed dose, skip it and just take your next scheduled dose. Do not take two doses at once.
If you take too much Lipitor or overdose, seek immediate medical care.
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What If I Forget To Take It
If you forget to take a dose, skip the missed dose and take your next one the next day at the usual time.
Never take 2 doses at the same time. Never take an extra dose to make up for the forgotten one.
If you forget doses often, it may help to set an alarm to remind you.
You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.
What Role Does Genetics Play In Determining Cholesterol Levels
In addition to environmental factors like diet and drugs, inherited genetic factors influence an individuals cholesterol level and how that level responds to various cholesterol-lowering strategies.
However, environmental influences are probably significantly more important. The Tarahumara Indians of northwestern Mexico, for example, traditionally have low cholesterol levels you could say its in their genes. But a study by scientists at Oregon Health Sciences University found that the Tarahumaras cholesterol levels rose sharply, and in just a few weeks, when they were directed by the researchers to switch from their traditional fiber-rich, plant-based diet to a Western-style diet full of cheese, butter, oils, egg yolks, white flour, soft drinks, and sugar.5
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What Should I Know About Storage And Disposal Of This Medication
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture .
It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.
Before Taking This Medicine
You should not take Crestor if you are allergic to rosuvastatin, or if you have:
liver disease/high levels of liver enzymes in your blood or
if you are pregnant or breastfeeding.
Do not take Crestor if you are pregnant. Rosuvastatin could harm the unborn baby or cause birth defects. Stop taking this medicine and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking this medicine.
Rosuvastatin may pass into breast milk and could harm a nursing baby. Do not breastfeed while you are taking this medicine.
To make sure Crestor is safe for you, tell your doctor if you have ever had:
a habit of drinking more than 2 alcoholic beverages per day
if you are of Asian descent or
if you are 65 or older.
Crestor can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism .
People of Asian descent may absorb rosuvastatin at a higher rate than other people which may cause muscle weakness/dysfunction. Make sure your doctor knows if you are Asian. You may need a lower than normal starting dose.
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How To Use Rosuvastatin
- Before you begin taking rosuvastatin 10 mg, and each time you get a refill, read the Patient Information Leaflet if it is available from your pharmacist.
- If you are taking this medication in capsule form, swallow the capsules whole. The capsules should not be crushed, broke, or chewed. If you have difficulty swallowing open the capsule carefully and sprinkle the contents on 1 teaspoon of soft food . Without chewing, swallow the entire mixture. Use/throw out the mixture within 60 minutes. Make no advance preparations for the next dose.
- The dosage is determined by your medical condition, response to treatment, age, race, and any other medications you are currently taking.
- Aluminum or magnesium-containing antacids may reduce the absorption of this medication. As a result, if you take this type of antacid, you should do so at least 2 hours after taking this medication.
- To get the most out of this medication, take it on a regular basis. Keep in mind to take it at the same time each day. Even if you feel fine, continue to take this medication. The majority of people who have high cholesterol or triglycerides do not feel ill.
Myth #: Statins Frequently Cause Memory Loss
Truth: In 2012, the FDA changed statin drug labels to include information that some people had experienced memory loss and confusion while taking the medications.
Unfortunately, that change was based on some poor-quality studies and evidence, Martin explains. People became seriously concerned that lower cholesterol levels could affect the brains function. But in fact, the brain makes its own cholesterol. It doesnt depend on the cholesterol in the blood.
My colleagues and I at Johns Hopkins specifically researched the issue of statins impacting cognitive dysfunction or dementia, says Martin. We reviewed all the studies that had been done, and found that the most rigorous studies show that statins do not commonly cause memory loss. If anything, long-term use of statins might have a beneficial effect on the brain since they help prevent strokes and protect the health of arteries in the brain.
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