Timeline For Weight Gain
There is rapid weight gain in the first few weeks after commencing antipsychotics. The rate of weight gain then gradually decreases and flattens over several months. Time taken to plateau was different for each antipsychotic, ranging from 4 to 9 months for olanzapine and from 42 to 46 months for clozapine. This indicates that patients would continue to gain weight for 14 years. It is consistently reported that patients continue to gain weight over time.,
An interesting finding described by Bak et al was that weight increased more significantly during the period beyond 38 weeks than within the first 6 weeks for olanzapine and FGA group and for olanzapine alone in antipsychotic-naïve group.
Factors associated with rapid weight gain in the initial period were younger age, lower baseline body mass index , more robust response to antipsychotic and increase in appetite. Rapid weight gain of more than 5% in the first month is the best predictor for significant long-term weight gain.
What Drugs And Food Should I Avoid While Taking Zocor
Grapefruit may interact with simvastatin and lead to unwanted side effects. Avoid the use of grapefruit products.
Avoid eating foods high in fat or cholesterol, or simvastatin will not be as effective.
Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.
Common Side Effects Of All Statins
Side effects reported by some people include muscle pain and digestive problems.
Muscle pain is the most common side effect caused by statin use. A 2014 assessment found that intolerance of statins is a real issue usually noted as muscle-related symptoms. Its estimated that between 1 and 10 percent of muscle symptoms are related to statin use.
Muscle pain can be uncomfortable. However, you should call your doctor right away if you have:
- unusual muscle pain or cramps
- dark urine
These could be symptoms of rhabdomyolysis. This is a dangerous muscle breakdown condition that can cause kidney problems.
For more information on what puts you at risk of these effects, as well as how theyre treated, read about why statins cause muscle pain.
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Adopting A Diet And Exercise Program
Your doctor may suggest that you implement certain lifestyle changes before stopping the statin, or directly in place of the drug. These changes might include adopting an exercise program or modifying your diet. For example, the suggests following a Mediterranean diet or vegan diet.
Keep in mind, though, that these changes likely wont work as quickly or as effectively as a statin in lowering your cholesterol. A healthy diet and exercise program can have many benefits for your overall health, but it may not be enough to replace the cholesterol-lowering effects of a statin.
You and your doctor should closely monitor your cholesterol levels to make sure the diet and exercise changes are having the necessary effects on your cholesterol.
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What About Other Cholesterol Drugs
It’s uncommon that ezetimibe is prescribed by itself, without other cholesterol drugs being used first.
In fact, it is most commonly taken with ‘statin’ medications, like Lipitor and Crestor .
Unlike ezetimibe, statin medications are associated with weight gain. However, the mechanism behind this, and whether or not it’s the statin drugs that cause weight specifically, is unknown.
The Tip Of The Iceberg
This is hardly the first time that scientists have detected a link between statins and type 2 diabetes. In 2011, analyzing more than 170,000 people from 76 trials, researchers discovered a 9% increased odds of diabetes among statin users.2
In an accompanying editorial3 on statin-induced diabetes, authors Mark Goldstein and L. Mascitelli wrote, Perhaps its the tip of the iceberg.
In another meta-analysis4 of more than 90,000 people, scientists from the University of Glasgow in the United Kingdom found an overall 9% increased risk of diabetes.
And following nearly 162,000 women aged 50 to 79 years, a study5 led by researchers from Mayo Clinic found that statin use was associated with a 48% increased risk for diabetes.
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Who Takes Statin Drugs
Close to 15-2o million people take statins. These drugs lower risk factors for heart disease. Doctors take a simple blood test to assess the amount of cholesterol levels in the blood. If there are high levels of bad cholesterol, there is a greater impact of heart disease, especially when factors increase risk. Doctors can also recommend taking statins to lower cholesterol by a certain specific percent.
Not all cholesterol is wrong for you. HDL or cholesterol that is good can make a vast difference to the plaque buildup in the arteries through the transportation of bad cholesterol to the liver from the blood.
Statins work through the blockage of action of enzymes in the liver that produces cholesterol. Excess cholesterol in the blood can cause plaque build-up in the artery walls. This can lead to arteriosclerosis or hardening of the arteries. This , in turn, can lead to increased chances of heart attack and cardiovascular stroke.
This high cholesterol blood medication lowers LDL cholesterol and total cholesterol level. Raising HDL cholesterol by lowering triglycerides, these statins can stabilize plaques in arteries. This decreases the chance of a heart attack.
Why No Obesity Drug Will Ever Be The Next Lipitor
Former Xenical User via Wikipedia
“The next Lipitor.” That’s the prediction Christopher James of investment bank MLV & Co. made for Vivus’ new obesity drug in a story last week. He was quoted as saying it could be given to tens of millions of patients.
Its not that Vivus drug, Qnexa, doesnt have potential to become the best-selling weight loss pill ever. Its that it could be many times bigger than any weight loss medicine ever and still not even come close to hitting Lipitors peak of $11 billion in global annual sales.
It seems intuitively obvious that the market for an obesity drug would be vast. But the reality is that obesity drugs have never sold in Lipitor-like numbers, and they are not likely to unless someone comes up with one that is absolutely perfect in terms of efficacy and side effects.
In the late 1990s, there was a huge fad of combining the weight loss drugs Pondimin , sold by American Home Products, and the stimulant phentermine. Doctors also started using Redux, a newer AHP weight loss drug. In 1996, its first year on the market, Redux had sales or $132 million, and Pondimin had sales of $48 million, according to a December 1997 Reuters story. In March 1997, both drugs were withdrawn because they appeared to increase the risk of heart valve defects.
Of course, that was all for naught. Acomplia raised the risk of neurological side effects, including suicidality, and was never approved in the U.S. and has been withdrawn worldwide.
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Can Antipsychotics Affect Blood Sugar
Weight gain, diabetes, and increases in lipid levels like cholesterol are the components of metabolic syndrome usually associated with antipsychotics. The mechanism may be from increased appetite or changes in metabolism.
- Second generation antipsychotics such as clozapine and olanzapine are linked with the greatest level of weight gain, blood sugar changes and lipid elevations, relative to other drugs in this class.
- Talk to your doctor before stopping or changing treatment. Your doctor can assess if a change in treatment is necessary. You may need to engage in extra exercise or diet modification, as well.
- Antipsychotics are a needed and important part of treatment for mental health conditions such as schizophrenia or bipolar disorder.
Is There Gluttony In The Time Of Statins
Recent data have affirmed this Tony Roma-style behavior.
In a 2014 study7 titled, Is There Gluttony in the Time of Statins? scientists from UCLA followed roughly 28,000 U.S. adults for more than a decade. They found that calorie intake increased by 10% and fat intake by 14% among statin users. Among those not taking statins, calorie and fat intake remained essentially the same.
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What Foods Should You Avoid When Taking Statins
You may have heard that you should not drink grapefruit juice with statins. From a chemical perspective, this only applies to statins that are metabolized by the CYP3A4 enzyme in the liver, because grapefruit interferes with this enzymethese statins include atorvastatin, simvastatin, and lovastatin 00774-3/fulltext” rel=”nofollow”> Lee, 2016). However, some evidence exists that suggests that, from a practical standpoint, there may not be an issue drinking grapefruit juice with statins . If you are a big grapefruit juice drinker, get medical advice before starting statins.
How And When To Take It
Take atorvastatin once a day. You can choose to take it at any time, as long as you stick to the same time every day.
Sometimes doctors may recommend taking it in the evening. This is because your body makes most cholesterol at night. If you’re not sure when to take your medicine, ask a pharmacist or your doctor for advice.
Atorvastatin doesn’t upset the stomach, so you can take it with or without food.
Swallow atorvastatin tablets whole with a glass of water. If you’ve been given chewable tablets, you can chew them or swallow them whole with a glass of water.
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Lipitor And Other Medications
Below are some of the medications that can interact with Lipitor. This section doesnt cover all drugs that may interact with Lipitor.
Before taking Lipitor, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Strong CYP3A4 inhibitors
CYP3A4 is an enzyme that helps your body break down drugs. Taking Lipitor with strong CYP3A4 inhibitors, which are medications that inhibit the activity of CYP3A4, can increase the levels of Lipitor in your body. This increases your risk for side effects from Lipitor.
Examples of strong CYP3A4 inhibitors include:
- certain antibiotics, such as clarithromycin and erythromycin
- certain antifungals, such as ketoconazole and itraconazole
- certain protease inhibitors, such as saquinavir and tipranavir
If youre taking any of these medications, you should talk with your doctor before taking Lipitor. They may lower your dose of Lipitor. Or they may prescribe you a different medication instead of a strong CYP3A4 inhibitor.
Cyclosporine or letermovir
If youre taking cyclosporine or letermovir, you should talk with your doctor before taking Lipitor. Theyll choose the best medications to safely treat your conditions.
Gemfibrozil and other fibrates
Can Corticosteroids Increase Appetite
Corticosteroids include drugs such as:
Corticosteroids are used for multiple conditions, including severe asthma, acute allergies or inflammatory disorders such as arthritis. These drugs can boost the metabolic rate and your appetite, too. High doses and long-term use of these agents may carry a significant risk of weight gain.
Local injectable corticosteroids and inhaled or nasal corticosteroids used for asthma or allergies are not associated with weight gain.
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Cholesterol Levels In Dialysis Patients
In a study of dialysis patients, those with higher cholesterol levels had lower mortality than those with low cholesterol.51 Yet the authors claimed that the inverse association of total cholesterol level with mortality in dialysis patients is likely due to the cholesterol-lowering effect of systemic inflammation and malnutrition, not to a protective effect of high cholesterol concentrations. Keeping an eye on further funding opportunities, the authors concluded: These findings support treatment of hypercholesterolemia in this population.
Can Natural Remedies Lower High Cholesterol Without Statins
Exercise on its own doesnt lower your LDL much often only a few points. Exercise helps minimize many heart disease risk factors, including obesity and Type 2 diabetes. Make a point to exercise five days a week for at least 30 minutes each day.Diet is incredibly important in managing your cholesterol.Every patient who comes to our preventive cardiology clinic for cholesterol management sees a nutritionist as part of the visit because we feel so strongly about the importance of diet. There are many patients for whom weve delayed prescribing statins, or suggested that they get off their medication if it isnt appropriate for their level of risk.Some patients think, Im on a statin I dont have to exercise, and I can eat whatever I want! But thats not the case. Lifestyle choices absolutely matter. For high-risk patients, its not a question of either improving the diet or getting on a medication, its both lifestyle changes and taking a statin together are necessary to protect high-risk patients against heart attack and stroke.If your cholesterol is borderline but not yet high, changing your diet and incorporating healthier food choices can help lower your cholesterol a decent amount. Eating more fiber and lowering your intake of saturated fat definitely can help. For people with relatively low risk, this may be enough to lower heart attack and stroke risk.
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How Do Doctors Decide Who Is Prescribed A Statin
- Have clinical atherosclerotic cardiovascular disease , including those with a personal history of stroke, heart attack, or peripheral vascular disease, and also those who suffer from chest pains
- Have high cholesterol
- Are age 40 to 75 and have diabetes
- Are age 40 to 75 and have an estimated 10-year risk of an ASCVD event greater than 7.5 percent
What Can I Do To Lower My Blood Sugar If I Am Already Taking Medication
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Muscle Pain & Cramping
Achy muscles are the most commonly reported side effect of not only Lipitor, but of statin medications in general. The tenderness is typically bilateralwhich means you feel it on both sides of your bodyand shows up in your larger muscle groups, like arms, legs, back, and shoulders. Cramping, however, normally takes place on one side of the body, or unilaterally.
Sometimes muscle pain is due to an interaction with another medication youre taking, or a sign that your thyroid or vitamin D level needs to be checked, says Amy Pollak, M.D., cardiologist at the Mayo Clinic. Other times, its a sign that your body doesnt tolerate the medication and that youre having a more serious reaction, called rhabdomyolysis.
Rhabdomyolysis occurs when muscle tissue breaks down, releasing into the blood stream. It can cause kidney damage or failure, and even death.
Amelia Sattler, M.D., family medicine doctor at Stanford Health Care, says dark, tea-colored pee is one good indication that your muscles are deteriorating. Rhabdomyolysis, however, only occurs in one in 10,000 patients on statins, according to Thomas, and usually happens when there is too much statin in the bloodstream.