Triglycerides High And Hdl Low

How The Triglycerides And Hdl Cholesterol Tests Are Done :

Triglycerides and HDL

If your doctor wants Triglycerides and HDL cholesterol tests on you, you may need to go through these tests. During the Triglycerides and HDL cholesterol blood tests, a pathologist will put a needle into your veins and take out a small quantity of blood. A pathologist is a physician in the medical field who thoroughly studies the causes and effects of disease. Within a few hours you will get your Triglycerides and HDL cholesterol Test reports by your pathologist.

Baseline Clinical Characteristics Of The Study Population

In the overall study population, the mean value of TG/HDL ratio was 2.78±2.37 and the median value was 2.095 . Demographic and clinical characteristics, cardiovascular risk factors and medication use are detailed in Table . In the whole population, mean age was 60±9 years and 59% of patients were men. Family history of CAD was present in 33% of patients and the majority of the population had atypical chest pain , hypercholesterolemia and hypertension . Diabetes was diagnosed in 112 and metabolic syndrome in 118 patients. In the different TG/HDL ratio quartiles, the frequency of male gender, diabetes, smoking habit and of the metabolic syndrome significantly increased from the I quartile to the IV quartile. Male patients and patients with diabetes, obesity and metabolic syndrome showed significantly higher TG/HDL ratio as compared with female patients or patients without diabetes, obesity and the metabolic syndrome, respectively . A significant increase across quartiles was found for BMI, the use of beta-blockers, diuretics and glucose-lowering agents.

Table 1 Clinical characteristics of the study population and of groups defined by TG/HDL-C quartiles. .Figure 1

TG/HDL-C ratio and cardio-metabolic risk. Relationship between baseline TG/HDL-C ratio, specific cardiovascular risk factors , and relevant bio-humoral variables .

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Complications Of High Cholesterol

Since high cholesterol alone typically doesnt cause any symptoms, people only experience complications when their high cholesterol contributes to the development of severe heart disease, often in the form of heart attack or stroke. Over the long term, high cholesterol can cause plaque to form in your arteries, which can then narrow and lead to a cardiovascular emergency.

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Lesson #: You Should Have To Prove That A Treatment Has An Outcome Effect Before It Becomes Widely Adopted And Biomarkers Are Not Enough

Ive gotten into disagreements with my colleagues about whether we should be prescribing drugs like bempedoic acid or inclisiran for patients with elevated LDL-cholesterol levels.

The argument for these drugs is that they lower LDL-cholesterol and apolipoprotein B via a final stage mechanism of action thats widely known to be effective: these drugs increase LDL receptors on the surface of liver cells, leading to more clearance of LDL from the bloodstream.

There is strong evidence that other classes of drugs that work via this mechanism – statins, ezetimibe, PCSK9 inhibitors – all lower cardiovascular risk.

But we dont have outcomes data for these drugs, which means that we dont know whether they reduce heart attacks, strokes, or death.

And so my argument is that when you dont have data, you dont really know whether the medication works.

The history of medicine is littered with drugs that *should have worked* but ultimately failed in clinical trials.

CETP inhibitors, drugs that raise HDL and lower LDL, are the quintessential example of this. These drugs are modeled after a genetic variation that seems to lead to longer lifespan.

Theres just one problem: torcetrapib, the CETP inhibitor that raised HDL and lowered LDL, unfortunately had the nasty side effect of increased risk of death.

There are two PCSK9 inhibitors that have been approved, alirocumab and evolocumab.

But alirocumab reduces the risk of death and evolocumab doesnt.

Normal Range Of Ldl Hdl Ratio : 05

Ideal values of LDL HDL ratio depending on age :

Age
> 100 years	0.62696

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High Hdl Cholesterol And Low Triglycerides Can Be Caused By Many Reasons

If your HDL cholesterol is in between 40 mg/dL and 60 mg/dL and your Triglycerides is in between 0 mg/dL and 150 mg/dL then you need not worry as these are the normal ranges for HDL cholesterol and Triglycerides respectively. But if your levels are lesser or greater than the above values, then there may be some problem in your body.

Questions To Ask Your Doctor

If testing shows you have high cholesterol, you may want to ask your doctor these questions at your next visit.

1. What are the dangers of having high cholesterol? Can other problems develop?

2. What could have caused my cholesterol to be too high? Is it inherited?

3. Are there things I can do at home or in my life to reduce my cholesterol?

4. Is medicine necessary? Are there alternative treatments?

5. If medicine is needed, how does the medicine work?

6. How long can I take medicine? What are the side effects? Is long-term use harmful?

7. How can exercise help to lower my cholesterol?

8. Where can I learn more about how to live with high cholesterol?

9. What changes should I make to the way I eat?

10. How often do I need to get my cholesterol level checked?

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What Can Affect My Ldl Level

Things that can affect your LDL level include:

Diet. Saturated fat and cholesterol in the food you eat make your blood cholesterol level rise
Weight. Being overweight tends to raise your LDL level, lower your HDL level, and increase your total cholesterol level
Physical Activity. A lack of physical activity can lead to weight gain, which can raise your LDL level
Smoking.Cigarette smoking lowers your HDL cholesterol. Since HDL helps to remove LDL from your arteries, if you have less HDL, that can contribute to you having a higher LDL level.
Age and Sex. As women and men get older, their cholesterol levels rise. Before the age of menopause, women have lower total cholesterol levels than men of the same age. After the age of menopause, womens LDL levels tend to rise.
Genetics. Your genes partly determine how much cholesterol your body makes. High cholesterol can run in families. For example, familial hypercholesterolemia is an inherited form of high blood cholesterol.

Lipid Levels And Heart Health

Silent CV Risk: Triglyceride/HDL Ratio

Cholesterol and triglycerides are necessary for your body to function properly. However, if too many triglycerides or LDL particles are in the bloodstream, they can stick to the walls of arteries and clog them, causing a disease called atherosclerosis, a major risk factor for heart attack and stroke. HDL cholesterol helps escort LDL particles out of the bloodstream, so an increased level of HDL lowers your risk of coronary diseases.

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Why The Test Is Performed

Triglycerides are usually measured together with other blood fats. Often it is done to help determine your risk of developing heart disease. A high triglyceride level may lead to atherosclerosis, which increases your risk for heart attack and stroke.

A very high triglyceride level may also cause swelling of your pancreas .

Lowering Your Triglyceride Levels

Making some simple lifestyle changes can go a long way in helping bring down your triglyceride levels, including:

Losing weight. Dropping just five to ten pounds can help lower your triglycerides.
Avoiding sugary and refined foods. Stay away from simple carbohydrates, such as sugar and foods made with white flour.
Eliminating trans and saturated fats. Trans fats are found in fried foods and commercial baked products like cookies and crackers and saturated fats are found in meats. Instead, choose healthier monounsaturated fats found in plants, such as olive, peanut and canola oils, and fish high in omega-3 fatty acids, such as salmon and mackerel.
Limiting alcohol consumption. Alcohol is high in calories and sugar and effects triglycerides. Even small amounts of alcohol can raise triglyceride levels.
Maintaining regular exercise. Regular exercise can increase HDL cholesterol levels and lower LDL cholesterol and triglyceride levels. Aim for at least 30 minutes of physical activity on most days of the week.

If making some lifestyle adjustments isnt enough to control your triglyceride levels, a medication may be necessary. Talk with your doctor to determine the best course of action for you to ensure a healthy heart.

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Understanding Cholesterol: Hdl Ldl And Triglycerides

There are two types of grocery shoppersthose who race in with a list in hand and meticulously grab every item on the list before checking out and leaving, and those who meander up and down every aisle, not sure what they want until they see it on the shelf.

But within those two types, theres another shopper you may have seenthe label-reader. This person is health-conscious and examines the nutrition labels of food items before placing them in the cart.

One of the most important categories to check for on a food label is cholesterol.

Cholesterol is a waxy, fat-like substance found in your blood. Your body needs some cholesterol, but too much can build up on the walls of your arteries and can lead to heart disease and stroke. Checking your risk for heart disease and stroke is as simple as getting a lipid panel, which tests your blood cholesterol.

There are four important things checked in a lipid panel:

Total cholesterol
Low-density lipoproteins

HDL is known as the good cholesterol because it helps remove cholesterol by carrying it back to the liver where it can be eliminated from the body. Its good to have a high HDL number. LDL is known as the bad cholesterol because having too much LDL may cause a buildup of plaque in your blood vessels. Triglycerides are also a type of fat found in your blood. High triglycerides, low HDL, and/or high LDL numbers can increase your risk for heart attack and stroke.

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Do You Need Medication To Control High Cholesterol

Whether youll need to take medication to lower your cholesterol depends on your levels, as well as on your other risk factors for heart disease, including your sex, age, health history, and family medical history.

Until recently, doctors decided whether or not to treat high cholesterol based on these numbers, explains Holly Andersen, MD, an attending cardiologist at NewYork-Presbyterian Hospital/Weill-Cornell Medical Center in New York City. Now, when it comes to deciding if youd benefit from taking medication to lower your cholesterol, your score is no longer a solo consideration, Dr. Andersen says. The change is a result of the November 2013 guideline on the assessment of cardiovascular risk issued jointly by the American Heart Association and the American College of Cardiology. These recommendations advise doctors to consider a patients overall health for heart disease, not just cholesterol numbers.

Some of the factors used to measure your heart disease risk are:

Your age, gender, and race
Whether you smoke
Whether you have diabetes

Your physician may plug your numbers and other factors into the ACC/AHA ASCVD Risk Estimator to determine your 10-year risk of heart disease or stroke. If you have the data, you can calculate the risk yourself using an online tool like this Heart Risk Calculator.

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High Cholesterol High Hdl Low Triglycerides

Dr T

Question: Answer:

There are 2 kinds of LDL cholesterol, A and B, of which B is associated with heart disease.Most labs calculate LDL as follows:

LDL = Total Cholesterol HDL triglycerides/5.

This doesnt explain the difference between LDL A or B .

Studies have shown that there is a strong correlation between a low triglyceride/high HDL level and LDL pattern A .

On the other hand, a high triglyceride/low HDL level is strongly associated with LDL pattern B . Thus high triglycerides are an independent risk factor for heart disease.

From this you can calculate that in your situation a high LDL is mostly Type A , confirmed by a high HDL and low triglyrerides and that therefore there a very low risk of heart disease.

Having high cholesterol may still be healthy if good cholesterol levels, triglycerides, and other markers of cardiovascular health are good. You can calculate this here. People with high good cholesterol levels and low levels of triglycerides may actually be at a lower risk for heart disease than people with normal cholesterol levels who have lower levels of good cholesterol and higher levels of bad cholesterol.

Hope this helps,

A Neutral Trial Like This Is A Wonderful Step Forward For Science

Ive written before that we get the type of evidence that we deem acceptable.

Trials like PROMINENT are an important step forward – they test the question of whether or not a drug does the thing that we want it to do.

While I may be a bit disappointed that the trial was ultimately neutral, Im thrilled that it was done, because its only through rigorously testing treatments that we ever find out what really works versus what we hope will work.

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Consult A Doctor For Your Ldl Hdl Ratio Problem

High LDL HDL ratio and low Triglycerides can be caused by a lot of reasons. If you take LDL HDL ratio and Triglycerides blood tests and the results are higher than 3 Ratio for LDL HDL ratio and lower than 0 mg/dL for Triglycerides, your physician may recommend more tests to figure out the problem. You might also get these tests if your physician thinks you have some other disease.

Can Lowering Carbs Actually Improve Tg/hdl Rc And Cv Risk

Dr. Stephen Phinney: Is it possible to have a high A1c and low triglycerides?

Yes. There is plenty of evidence showing this. Multiple studies range from clinical trials in animals and humans to meta-analyses. Here are 4 of them:

The Abbasi study was a human clinical trial using a crossover design. People ate high carbs for 2 weeks, then low carbs for 2 weeks, with a washout period of 2 weeks in between. The high-carb diet doubled TG levels, tripled remnant cholesterol, and lowered HDL by 15% .
The Wang study is a randomized clinical trial in laboratory mice .
The Volek study is a meta-analysis. It reviews pre-2005 studies which had already shown that low-carb diets decrease triglycerides and remnant cholesterol while increasing HDL cholesterol level .
The Ebbeling study was also a human subjects clinical trial. It was done at Harvard. Subjects on a low-carb diet had lower TG and higher HDL cholesterol. Also, researchers showed that low-carb diets were less likely to result in weight rebound due to improved energy expenditure and leptin .

My name is Ford Brewer. My team and I work to prevent heart attack, stroke, cancer, and dementia. Our goal is to help you understand how to prevent major killers and disablers. Most of them are driven by the process of cardiovascular inflammation.

If you want to know more about the science of preventive medicine or you have questions about certain aspects of your health, check out our webinars, membership programs, and online courses.

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Your Test Results: A Preview

Your test results will show your cholesterol levels in milligrams per deciliter of blood . Your total cholesterol and HDL cholesterol are among numerous factors your doctor can use to predict your lifetime or 10-year risk for a heart attack or stroke. Your doctor will also consider other risk factors, such as age, family history, smoking status, diabetes and high blood pressure.

Lipid profile or lipid panel is a blood test that will give you results for your HDL cholesterol, LDL cholesterol, triglycerides and total blood cholesterol.

Watch an animation about cholesterol score.

My Cholesterol Is Normal But My Triglycerides Are High: Why Is That

So both your HDL and LDL levels are where they should be, but your triglycerides are still high why is that?

Triglycerides become elevated due to excess calories that do not get burned off, and in turned get stored in fat cells. Statins are medications that primarily lower LDL cholesterol, but depending on the medication dose, can lower Triglycerides from 20 to 40 percent, Sai Hanumanthu MD, with the TriHealth Heart Institute explains.

There are steps you can take to lower your triglyceride levels while promoting good cardiovascular health, including:

Losing 5 to 10 pounds if overweight
Avoiding alcohol
Avoiding foods high in saturated fats
Limiting simple carbs that have high processed sugars .
Participating in 30 minutes of exercise per day

All these suggestions and routine follow up with a medical professional will lower you triglyceride level, even despite a low total cholesterol, Dr. Hanumanthu says.

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When To Contact A Doctor

While high triglyceride levels may not usually cause symptoms, anyone who is uncertain or concerned about their triglyceride levels should consult a doctor.

Additionally, any adult who has not had a lipid profile test in the last 46 years should speak with a doctor about their cardiovascular risk factors and possible need for a test. Catching elevated levels of health markers, such as triglycerides or cholesterol, at an early stage may help a person make changes earlier to address the underlying issue.

Nutrition / Diet

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Arnett, D. K., et al. . 2019 ACC/AHA Guideline on the primary prevention of cardiovascular disease: A report of the American College of Cardiology/American Heart Association Task Force on clinical practice guidelines.