Are There Any Food Or Drinks I Should Avoid
Some foods affect the way your liver can process the statin, increasing the risk of side effects. Grapefruit is a common food that has this effect with some statins. Doctors generally recommend that you eat no more than half a grapefruit or drink no more than a 200ml glass of grapefruit juice each day if you are taking some statins. Check with your pharmacist if this applies to the statin you are taking.Statins can affect your liver, so you should avoid regularly drinking large quantities of alcohol while taking them. This can increase your risk of muscle problems.
Which Statins Are The Best For Preventing Cardiovascular Disease
There isnt a clear winner. This is because clinical trials of statins involve a wide variety of participants, drug doses, and outcomes of interest. To date, there has been no clinical trial that directly compares all of the available statins in a head-to-head fashion.
Heres the evidence we have so far:
A study followed patients after they had a heart attack to see if patients on different statins were less likely to have another heart attack or die. There was no difference. Patients on atorvastatin, pravastatin, simvastatin, lovastatin, or fluvastatin had the same risk.
An analysis of indirect comparisons found no significant difference between pravastatin, simvastatin, and atorvastatin for preventing cardiovascular disease.
An analysis of direct and indirect comparisons found that atorvastatin, fluvastatin, and simvastatin were more effective than lovastatin, pravastatin, and rosuvastatin for preventing heart disease and death.
Another analysis of direct and indirect comparisons found some differences among statins that varied according to the types of health problems that were studied.
Will Statins Increase My Risk For Diabetes Or Complicate My Existing Diabetes
This risk is true to some extent, but its wildly exaggerated.In fact, there are good data to show that people who have problems with their blood sugar or who have diabetes benefit most from statins. Even though their blood sugar may go up slightly, the added risk is significantly offset by the reduction in heart disease risk that a statin can provide.If youre already at risk for developing Type 2 diabetes, or if you have prediabetes, you may monitor your blood glucose more closely after starting a statin. But exercise and weight loss have been shown to lower the risk of developing diabetes in those with borderline blood glucose levels, regardless of statin use.
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Lifestyle Therapy: The First Step
With so many people in need and so many medications available, it’s understandable that both doctors and their patients are tempted to rely on medications to improve unhealthy cholesterol levels. That’s a mistake. Instead, lifestyle therapy is the place to start. That means avoiding tobacco in all its forms. It also means choosing foods low in saturated fat, trans-fatty acids, and cholesterol while favoring foods that provide heart-healthy omega-3 and monounsaturated fats and large amounts of dietary fiber. It also requires regular exercise, which can be as simple as walking at a moderate pace for at least 30 minutes nearly every day. And the combination of a good diet and regular exercise should help men achieve another important goal, weight control.
Lifestyle therapy can improve cholesterol levels, and certain foods can provide extra help . But even with clean living, many people need medication to achieve optimal cholesterol levels, particularly when they have to reduce their LDL levels to 100 mg/dL or less. It’s important to keep up a good diet and exercise program even if you take medication. And if you can’t take a statin, here is a rundown of other medications that can help Table 3 summarizes their effects on blood lipids and compares them to the statins.
How Do I Know If My Cholesterol Is Too High
There are no symptoms that can warn you when your cholesterol level is high. You can have high cholesterol and never know it. A lipid panel blood test is the only way to determine whether or not you have high cholesterol.
It is generally recommended that men and women over 20 years of age should have their cholesterol levels checked every 5 years. However, if your test results are outside of the recommended range, you should check them more often. Other factors related to your health, your family medical history and your lifestyle will also affect how often you should have your cholesterol levels checked. As always, talk to your doctor about the frequency that is best for you.
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Top 10 High Cholesterol Medications List By Popularity
High cholesterol medications are often the first line of defense when LDL levels become elevated. This is because it many cases they are effective at reducing the level of bad cholesterol in the blood stream, because they work to reduce the amount of cholesterol produced by the liver. These lipid lowering medications are even more effective when combined with healthy lifestyle practices such as limiting bad fat intake, reducing simple sugar intake, quitting smoking, increasing physical activity and losing weight.
The most common of these medications are referred to as statin drugs. Understanding their function first means understanding what is cholesterol in the first place. Cholesterol is a substance that the body needs to carry out necessary functions like using energy, building cells and producing hormones. Only about a quarter of it is derived from food sources. The majority comes from the livers manufacturing center, and how much it produces depends on many factors like lifestyle and genetics. Since the large part of cholesterol is made in the liver, these high cholesterol medications exert their energy there, by inhibiting the production of the HMG-CoA reductase enzyme, which contributes to the livers ability to make cholesterol, according to Wikipedia.
Effect Of Statin Therapy On Clinical Outcomes
A large number of studies using a variety of statins in diverse patient populations have shown that statin therapy reduces atherosclerotic cardiovascular disease. The Cholesterol Treatment Trialists have published meta-analyses derived from individual subject data. Their first publication included data from 14 trials with over 90,000 subjects . There was a 12% reduction in all-cause mortality in the statin treated subjects, which was mainly due to a 19% reduction in coronary heart disease deaths. Non-vascular causes of death were similar in the statin and placebo groups indicating that statin therapy and lowering LDL-C did not increase the risk of death from other causes such as cancer, respiratory disease, etc. Of particular note there was a 23% decrease in major coronary events per 1 mmol/L reduction in LDL-C. Decreases in other vascular outcomes including non-fatal MI, coronary heart disease death, vascular surgery, and stroke were also reduced by 20-25% per 1 mmol/L reduction in LDL-C. Additionally, analysis of these studies demonstrated that the greater the reduction in absolute LDL-C levels the greater the decrease in cardiovascular events. For example, while a 40mg/dl decrease in LDL-C will reduce coronary events by approximately 20%, an 80mg/dl decrease in LDL-C will reduce events by approximately 40%. These results support aggressive lipid lowering with statin therapy.
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Can I Use Crestor Or Lipitor With Alcohol
Generally, it is safe to consume a small to moderate amount of alcohol if you take Crestor or Lipitor. However, if you have liver problems, or drink an excessive amount of alcohol, check with your healthcare provider before mixing a statin and alcohol. People with chronic liver disease should avoid alcohol completely when taking a statin.
Effect Of Bile Acid Sequestrants On Clinical Outcomes
The Lipid Research Clinics Coronary Primary Prevention Trial of cholestyramine vs. placebo was the first large drug study to explore the effect of specifically lowering LDL-C on cardiovascular outcomes . LRC-CPPT was a multicenter, randomized, double-blind study in 3,806 asymptomatic middle-aged men with primary hypercholesterolemia. The treatment group received cholestyramine 24 grams per day and the control group received a placebo for an average of 7.4 years. In the cholestyramine group total and LDL-C was decreased by 8.5% and 12.6% as compared to the placebo group. In the cholestyramine group there was a 19% reduction in risk of the primary end point accounted for by a 24% reduction in definite CHD death and a 19% reduction in nonfatal myocardial infarction. In addition, the incidence rates for new positive exercise tests, angina, and coronary bypass surgery were reduced by 25%, 20%, and 21%, respectively, in the cholestyramine group. The reduction in events correlated with the decrease in LDL-C levels . Of note, compliance with cholestyramine 24 grams per day was limited with many patients taking much less than the prescribed doses. These results indicate that lowering LDL-C with bile acid sequestrant monotherapy will reduce cardiovascular disease.
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Controversy Means 6m Don’t Take Life
Some seven million Britons take statins every day to reduce cholesterol and ward off heart disease. But another six million could take the pills, but don’t.
A row over the pros and cons of statins have put many people off.
Since 2014 all over-75s, most over-60s and many in middle age have been eligible for the prescription medication.
For many who have heart disease or high blood pressure particularly those who have already suffered a heart attack or stroke statins are proven lifesavers, slashing the chance of a repeat attack.
Critics say healthy people should not take them ‘just in case’ as this amounts to ‘over-medicalisation’.
But most cardiologists are in favour of the ‘primary prevention’ approach, pointing out that the drugs cost just £20 a year per patient and prevent an estimated 80,000 heart attacks and strokes annually.
Experts are divided about the potential side effects of statins.
A 2016 paper published in the JAMA medical journal said between 5 per cent and 20 per cent of people who take statins stop taking the drugs because of muscle pain.
Others insist the side effects are vanishingly small and claim patients incorrectly blame any back pain or muscle ache on the drugs, when in fact most problems have a different cause entirely.
Kausik Ray, Professor of Public Health at Imperial College London who led the trials, said bempedoic acid finally gave an alternative.
Vytorin: Zocor + Zetia
A study published in the New England Journal of Medicine in 2008 found that Vytorin was less effective at reducing risk of heart disease compared to taking Zocor alone. Researchers found that while Vytorin was more effective at lowering cholesterol, it was not better at reducing plaque build up in the arteries compared to Zocor alone. In fact, the arterial wall was thicker for patients taking Vytorin. Two patients taking the combination pill died, compared to one taking Zocor, and three of the patients taking the combination pill had non-fatal heart attacks, compared to two taking Zocor. These differences were not statistically significant, meaning they could happen by chance, but they suggest that Zocor alone is a better choice than Vytorin. The final results of the two-year clinical trial indicated that patients taking Vytorin were at the same risk of heart disease as the patients who took Zocor alone. Why take 2 drugs at once if the second one is not helpful and may be harmful? : Vytorin is not more effective than Zocor alone.
After the above study was published, doctors were advised that Zetia should only be used if all other medications have failed. The listed side effects for Zetia include: stomach pain, tiredness, allergic reactions, and joint pain. Rarely, patients also experience severe muscle problems with symptoms of muscle pain, tenderness, or weakness caused by muscle breakdown.
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Effect On Bempedoic On Lipid And Lipoprotein Levels
EFFECT WITHOUT STATINS
In a study that randomized 345 patients with hypercholesterolemia .and a history of intolerance to statin to bempedoic acid or placebo bempedoic acid decreased LDL-C by 21.4%, non-HDL-C by 17.9%, and apolipoprotein B by 15% . One third of patients were on background non-statin therapy most commonly ezetimibe and fish oil. Triglyceride levels were not altered but there was a small decrease in HDL-C levels that was statistically significant .
IN COMBINATION WITH STATINS
Notably, the addition of bempedoic acid to atorvastatin 80mg per day was still capable of significantly decreasing LDL-C , non-HDL-C , and apolipoprotein B compared to placebo . The addition of bempedoic acid to high dose atorvastatin therapy did not cause meaningful changes in atorvastatin pharmacokinetics.
IN COMBINATION WITH STATIN AND EZETIMIBE
Truths About Statins And High Cholesterol
For every drop of scientific evidence that statins are safe and effective, there is a tidal wave of misinformation. Our patients are concerned about statin side effects theyve heard about from family or friends, or read about on the Internet.Statins are the gold-standard for high cholesterol treatment. Theyre a powerful medication, and theyve been proven to save the lives of many men and women living with or having a high risk of heart attack or stroke.But if statins are so effective, why are some people afraid to take them?As with any medication, there are risks associated with taking statins, but the benefits far outweigh the risks for the vast majority of high-risk patients.In an effort to put statin side effects into context and provide honest, scientific answers about statins and their use, weve put together a list of common questions our patients ask us:
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How Statin Drugs Protect The Heart
More than 200 million people around the world take statin drugs for theirheart health. Shifting ideas about the risks and benefits of statins overthe years, however, have left some new patients confused about whetherthese drugs are rightor safefor them.
Traditionally, statins were viewed as purely cholesterol-lowering drugs. So it made sense just to use them for people with high cholesterol, explains Johns Hopkins cardiologist Michael Blaha, M.D.But weve learned that they also benefit people with lower levels of cholesterol who are at a high risk of heart disease. So we now think of statins as risk-reducing drugs.
This dramatic change in thinking means that people who once were not candidates for statins are now prescribed them to lower their risk of heart attack and stroke.
Who Should Buy A Cholesterol Supplement
Cholesterol supplements are usually taken by those who need to lower the LDL cholesterol levels. Most people realize that their levels are off after a trip to their doctor. Typically, they are given medication and prompted to make dietary changes. However, supplements can also be used besides these strategies to see faster results.
If this describes you, a cholesterol supplement may be just what youre looking for. These supplements contain a wide variety of ingredients. If one doesnt work, another one might. Feel free to try multiple supplements to find which one works best for you.
Cholesterol supplements may also be useful for those who are worried about their heart health. Many of these supplements are also very heart-healthy, which is extremely useful if youre at risk for heart disease or other heart problems. Whether you have a family history of heart disease or just want to protect your heart, these supplements can also be useful in these cases.
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Mechanism Accounting For The Mipomersen Induced Lipid Effects
Apolipoprotein B 100 is the main structural protein of VLDL and LDL and is required for the formation of VLDL and LDL . Familiar Hypobetalipoproteinemia is a genetic disorder due to a mutation of one apolipoprotein B allele that is characterized by very low concentrations of LDL and apolipoprotein B due to the decreased production of lipoproteins by the liver . Mipomersen, an apolipoprotein B antisense oligonucleotide, mimics Familiar Hypobetalipoproteinemia by inhibiting apolipoprotein B 100 production in the liver by pairing with apolipoprotein B mRNA preventing its translation . This decrease in apolipoprotein B synthesis results in a decrease in hepatic VLDL production leading to a decrease in LDL levels.
Common Side Effects Of Crestor Vs Lipitor
The most common side effects of Crestor are headache, muscle pain, abdominal pain, nausea, and weakness.
Lipitorâs most common adverse effects are the common cold, joint pain, diarrhea, pain in extremities, and urinary tract infections.
A rare but serious side effect of Crestor and Lipitor is myopathy and rhabdomyolysis . See the warnings section for more information.
The occurrence of side effects may vary with dosage. This is not a full list of side effects. Other, serious side effects may occur. Talk to your healthcare provider about what side effects to expect from Crestor or Lipitor, and how to address them.
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Get Medical Advice From Your Doctor Not The Internet
Though statins are incredibly effective, there are many different forms of heart disease. Heart disease is still the No. 1 killer of men and women in our country, and the epidemic is spreading throughout the world. As long as the battle continues, well continue researching new ways to prevent and treat heart disease.
Symptoms Of High Cholesterol
High cholesterol doesnât have symptoms. So you can be unaware that your levels are getting too high. Thatâs why itâs important to find out what your cholesterol numbers are. If they’re too high, lowering them will lessen your risk for getting heart disease. And if you already have heart disease, lowering cholesterol can reduce your odds of a heart attack or of dying from heart disease.
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What Is High Cholesterol
There are two major forms of cholesterol: Low-density lipoprotein or LDL, also known as “bad” cholesterol, and high-density lipoprotein or HDL, also called “good” cholesterol. LDL is the main source of artery-clogging plaque. HDL, on the other hand, clears cholesterol from your blood.
Besides LDL and HDL, thereâs another kind of fat in your blood called triglycerides. Research shows that high levels of triglycerides, just like high levels of LDL, are linked to heart disease.
Your body needs cholesterol to build new cells, insulate nerves, and make hormones. Having too much, though, is a major risk for heart disease.
Ordinarily, your liver makes all the cholesterol your body needs. But you also get cholesterol from food. You’ll find these in many processed foods like doughnuts, frozen pizza, cookies, and crackers. You can also get it from milk, eggs, meat, and other animal products. Over time, without your even being aware, this extra cholesterol collects inside your body and begins to do damage.