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Is There Medicine To Lower Triglycerides

Effect On Inclisiran On Lipid And Lipoprotein Levels

Lowering Triglycerides – Mayo Clinic

HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

The effect of inclisiran on LDL-C levels was determined in patients with heterozygous familial hypercholesterolemia who were randomized to receive subcutaneous injections of inclisiran 284mg or placebo on days 1, 90, 270, and 450 . The mean baseline LDL-C level was 153±54mg/dl and 90% of the patients were receiving statins with most on high intensity statins . At day 510 LDL-C levels were reduced by 47.9% compared to placebo . The reduction in LDL-C was similar in all genotypes of familial hypercholesterolemia. Total cholesterol was reduced by 33%, non-HDL-C by 44%, Lp by 17.2%, and triglycerides by 12%. HDL-C and hsCRP were not markedly altered.

HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

A small study reported that inclisiran treatment lowered LDL-C levels in 3 of 4 patients with homozygous familiar hypercholesterolemia but less than that seen in individuals with fully functioning LDL receptors .

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Mechanisms Accounting For The Volanesorsen Induced Lipid Effects

Volanesorsen binds to apo C-III mRNA leading to increased degradation and thereby inhibits the hepatic synthesis of apo C-III protein resulting in a reduction in plasma apo C-III levels . Apo C-III has a number of important effects on the metabolism of TG rich lipoproteins . Apo C-III is an inhibitor of LPL and therefore decreasing apo C-III levels will enhance LPL activity. In patients with FCS this will not be important because patients with this disorder have defects in components of the LPL complex that result in the inability to increase LPL activity. Studies have shown that apo C-III stimulates the production and secretion of VLDL by the liver. This effect is also not likely to be of primary importance in patients with FCS as the very high TG levels are primarily due to chylomicrons and not VLDL. Whether apo C-III regulates chylomicron secretion by the intestine is unknown. Finally, and most importantly, Apo C-III inhibits the binding of TG rich lipoproteins to hepatic LDL receptors and LDL receptorrelated protein 1 decreasing the clearance of TG rich lipoprotein particles. A decrease in apo C-III will accelerate the clearance of TG rich lipoproteins, which likely accounts for the ability of volanesorsen to decrease TG levels in patients with FCS.

How Long Will I Need Cholesterol Medication

Typically, people who take cholesterol medication need it for the rest of their lives, and youre more likely to need it as you get older. However, children and teens can have high cholesterol, too. Lifestyle changes can often prevent the need for medication or work with medication to lower your risk of coronary artery disease.

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What Are Some Things That May Contribute To High Cholesterol And Triglycerides

We often associate high cholesterol and triglyceride levels with obesity, stress, lack of exercise, smoking, alcohol consumption, and poor diet. However, there are many things that may contribute to these conditions.

One of the most common causes of high cholesterol and triglycerides is a diet rich in saturated fats. Saturated fat is found in red meat, dairy products, butter, cheese, and eggs. These foods contain large amounts of cholesterol and saturated fat.

Another cause of high cholesterol and triglyceride levels is a diet lacking in fiber. Fiber helps lower cholesterol and triglycerides by removing excess cholesterol and triglycerides from the body.

Other factors that may contribute to high cholesterol and triglyceride include genetics, age, gender, hormones, medications, and lifestyle choices.

To reduce your risk of developing high cholesterol and triglycerides, try making some simple dietary changes. Avoiding processed food and eating more fruits, vegetables, whole grains, beans, nuts, seeds, fish, and poultry may help.

Also, avoid trans fats, which are found in fried foods, baked goods, snack foods, and fast food. Trans fats raise bad cholesterol and decrease good cholesterol . Theyre linked to heart disease, stroke, diabetes, and weight gain.

Address Underlying Health Issues

Healthy Cholesterol &  Triglycerides 60 capsules

Remember, although triglycerides can be high due to bad lifestyle and dietary choices, they can also be high due to an underlying health condition. The most important thing is to work with your doctor to find out whats causing your high triglyceride levels and to treat any underlying conditions!

For example, triglycerides can be high due to liver disease, infections, underactive thyroid , autoimmune disease, or some genetic disorders just to name a few .

In these cases, simply changing your diet or lifestyle wont help address the underlying issue and may actually be harmful!

In addition, high triglyceride levels can be dangerous for your body. If necessary, your doctor will prescribe triglyceride-lowering medication.

Thats why, if your triglycerides are elevated, you should discuss the lifestyle and dietary changes listed below with your doctor. None of these strategies should ever be done in place of what your doctor recommends or prescribes!

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Who Can Take Statins

You might be prescribed a statin if you have heart disease or another disease of the heart and blood vessels, or if you are at risk of developing them in the next 10 years.

If you have high cholesterol

You should be offered a statin if you have high cholesterol and lifestyle changes havent been enough to bring it under control.

Depending on your cholesterol levels and how healthy you are otherwise, you and your doctor or nurse might want you to try to bring your cholesterol levels down with a healthy diet and lifestyle first, before starting statins.

If you are at risk of developing heart disease

You will probably be prescribed a statin if you are at high risk of developing heart disease or a disease of the blood vessels. For example, if you have:

Will A Keto Diet Lower Triglycerides And Cholesterol

No, keto diets have been shown to increase cholesterol levels. The Mediterranean diet, however, has been shown to lower cholesterol levels and reduce the risk of cardiac events.

The Mediterranean diet promotes eating vegetables, fruits, whole grains, and healthy fats daily eating fish, poultry, beans, and eggs weekly reducing portions of dairy and limiting red meat.

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Risks And Side Effects

Although most people benefit from statins, these drugs can have side effects. The most serious side effects occur in people who are taking other medications or who have an underlying health condition. Many side effects go away as your body adapts to the medication.

The most common side effect of statins is muscle and joint aches and pains. The medication can also cause nausea and vomiting.

More serious side effects include liver and kidney damage, an increase in blood sugar, and neurological side effects. In some people, statins can cause a breakdown in muscle cells and lead to permanent muscle damage.

Why Is There Tg In The Blood

High Triglycerides: Is Your Medicine Causing It?? (11 Culprits)

The most common reason for elevated triglycerides is prediabetes. Chronically high insulin stimulates adipokines and hormone-sensitive lipase. This results in the release of too many fatty acids from fat cells. These excess fatty acids take up space in HDL and LDL particles.

TG can also become elevated in several inherited diseases.

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How Do I Know If My Cholesterol Levels Are High

High blood cholesterol levels are a major cause of heart attacks and strokes. They also lead to clogged arteries and increased blood pressure. To reduce your risk for these conditions, keep your total cholesterol level below 200 mg/dL. This means that your HDL and triglyceride levels must be above 40 mg/dL and 150 mg/dL, respectively.

The following tests can help determine whether your cholesterol levels are too high. If you have any symptoms of high cholesterol, such as chest pain, shortness of breath, leg swelling, or arm numbness, speak with your doctor immediately.

  • Total cholesterol test A simple blood test that measures the amount of total cholesterol in your blood. Your doctor may recommend this test when you first visit him or her because it can give clues about your overall health.
  • HDL cholesterol test A blood test that measures the HDL cholesterol in your blood. High HDL cholesterol levels indicate a healthy lifestyle.
  • LDL cholesterol test A simple cholesterol test that measures the amount of LDL cholesterol in your blood.

About 38% of American adults have high cholesterol (total blood cholesterol 200 mg

Increase Your Intake Of Unsaturated Fats

Studies show that monounsaturated and polyunsaturated fats can reduce blood triglyceride levels, especially when theyre replacing carbs in your diet .

Monounsaturated fats are found in foods like olive oil, nuts, and avocados. Polyunsaturated fats are present in vegetable oils and fatty fish, as well as nuts and seeds such as walnuts, flaxseeds, and chia seeds.

A 2019 review of 27 studies reported that while olive oil consumption does decrease triglycerides levels, it does so significantly less than other types of plant oil .

One older study analyzed the diets of 452 adults in a specific population of Indigenous people in Alaska over the previous 24 hours.

It found that saturated fat intake was associated with increased blood triglycerides, while polyunsaturated fat intake was associated with lower triglyceride levels .

To maximize the triglyceride-lowering benefits of unsaturated fats, pick a heart-healthy fat like olive oil and use it to replace other types of fat in your diet, such as trans fats or highly processed vegetable oils .

Summary

Monounsaturated and polyunsaturated fats can decrease blood triglyceride levels, especially when theyre consumed in place of other fats.

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Effect Of Pcsk Inhibitors On Lipid And Lipoprotein Levels

There are a large number of studies that have examined the effect of PCSK9 inhibitors on lipid and lipoprotein levels. A meta-analysis of 24 studies comprising 10,159 patients reported a reduction in LDL-C levels of approximately 50% and in an increase in HDL of 5-8% . Notably, in 12 RCTs with 6,566 patients, Lp levels were reduced by 25-30% . The higher the baseline Lp the greater the reduction with treatment . It should be recognized that most LDL-C lowering drugs do not lower Lp levels. PCSK9 inhibitors have not been shown to decrease hs-CRP levels .

MONOTHERAPY

Both alirocumab and evolocumab have been studied as monotherapy vs. ezetimibe. In the Mendel-2 study patients were randomly assigned to evolocumab, placebo, or ezetimibe . In the evolocumab group, LDL-C levels decreased by 57% while in the ezetimibe group LDL-C levels decreased by 18% compared to placebo. Additionally, non-HDL-C was decreased by 49%, apolipoprotein B by 47%, triglycerides by 5.3% , and Lp by 18.5% while HDL levels increased by 5.5% in the evolocumab treated subjects. In a study of alirocumab vs. ezetimibe, LDL-C levels were reduced by 47% in the alirocumab group and 16% in the ezetimibe group . In addition, alirocumab decreased non-HDL-C by 41%, apolipoprotein B by 37%, triglycerides by 12%, and Lp by 17% and increased HDL by 6%. Thus, PCSK9 monoclonal antibodies are very effective in lowering pro-atherogenic lipoproteins when used in monotherapy and have a more robust effect than ezetimibe.

Alternatives To Statins For Lowering Cholesterol

Lower Cholesterol and Reduce Triglycerides Without Statin Drugs

Your best treatment option for high cholesterol depends on many factors.

Before your doctor recommends a prescription medication, they will look at several things, such as:

  • your family medical history
  • your risk for heart disease

Many doctors prefer to start with changes to diet and exercise. If those changes dont have enough effect, you might start taking medication to help the process along.

Statins are one commonly prescribed medication for controlling cholesterol, but these drugs might not be right for everyone. There are several treatment options for high cholesterol, including other medications and lifestyle changes.

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Dos And Donts In Managing High Triglycerides:

  • DO exercise regularly.
  • DO eat more fruits and vegetables and high-fiber foods such as oat bran. Cook with monounsaturated fatsolive, peanut, and canola oils.
  • DO stop smoking.
  • DO lose weight by changing your diet and doing aerobic exercise, such as walking, jogging, bicycling, or swimming. Exercise at least 30 minutes daily.
  • DONT forget to treat other medical conditions such as diabetes and underactive thyroid.
  • DONT drink more than two alcoholic drinks per day.
  • DONT change your diet or medicines without your doctors approval.

Top Foods To Help Lower Triglyceride Levels

Triglycerides are a type of fat found in your body. Elevated levels are linked to an increased risk of cardiovascular disease .

Diet plays a major role in the production of triglycerides in your body. Certain foods may even help lower your blood levels.

Here are 8 top foods that may help lower triglyceride levels.

5 ).

Daily intakes of at least 25 grams of soy protein were most effective at lowering these fats in the blood .

Soybeans, edamame, tofu, and tempeh are excellent sources of isoflavones, a health-promoting compound linked to reduced triglycerides, weight management, and improved menopause symptoms .

Fermented soy products like natto and tempeh have a higher nutritional value than unfermented soy. When used to replace sources of animal protein, they have a potent triglyceride-lowering effect .

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Possible New Treatment For High Triglycerides

In the report in The New England Journal of Medicine, an international team of researchers describe a new therapy for high triglycerides. It involves a weekly injection of antisense oligonucleotides , pieces of DNA that short-circuit the livers production of triglycerides. The new report shows that ASOs can reduce triglyceride levels by as much as 70%.

Keep in mind that this was a phase 2 trial, which is designed to test whether a drug does what it is supposed to do . Larger, longer-term studies will be needed to see whether ASOs actually reduce the risk of heart disease, and what sorts of side effects they cause.

Many experimental medications that sparkle in early testing never become FDA-approved drugs. We wont know for several years whether ASOs will become available for individuals with high triglycerides.

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Mechanism Accounting For The Pcsk9 Inhibitor Induced Lipid Effects

Lower TRIGLYCERIDES Quickly (Simple Steps) 2022

The linkage of PCSK9 with lipoprotein metabolism was first identified by Abifadel and colleagues in 2003, when they demonstrated that certain mutations in PCSK9 could result in the phenotypic appearance of Familiar Hypercholesterolemia . Subsequent studies demonstrated that gain of function mutations in PCSK9 are an uncommon cause of Familiar Hypercholesterolemia . In 2005 it was shown that loss of function mutations in PCSK9 resulted in lower LDL-C levels and this decrease in LDL-C levels is associated with a reduction in the risk of cardiovascular events .

The main route of clearance of clearance of plasma LDL is via LDL receptors in the liver . When the LDL particle binds to the LDL receptor the LDL particle- LDL receptor complex is taken into the liver by endocytosis . The LDL particle and the LDL receptor then disassociate and the LDL lipoprotein particle is delivered to lysosomes where it is degraded and the LDL receptor returns to the plasma membrane . After endocytosis LDL receptors recirculate back to the plasma membrane over 100 times.

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How To Use Lopid

Take this medication by mouth as directed by your doctor, usually twice a day .

Dosage is based on your medical condition and response to treatment.

If you also take certain other drugs to lower your cholesterol , take gemfibrozil at least 1 hour before or at least 4-6 hours after taking these medications. These products can react with gemfibrozil, preventing its full absorption.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same times each day. Keep taking this medication even if you feel well. Most people with high cholesterol/triglycerides do not feel sick.

It is very important to continue to follow your doctor’s advice about diet and exercise. It may take up to 3 months before you get the full benefit of this drug.

How Can Triglyceride Levels Be Lowered

If your triglyceride levels are high, the next step is for your doctor to check for potential causes. Certain medications, thyroid function issues, poorly controlled diabetes, liver or kidney disease can all cause triglyceride levels to be higher than normal.

The first steps in treatment to lower triglyceride levels include eating a healthy diet, achieving and maintaining a healthy weight, and aerobic exercise on a regular basis.

To lower your triglyceride levels, your diet should be:

  • low in simple carbohydrates

If you have high triglycerides and low HDL or high LDL levels, you may need to take medication along with making lifestyle changes. If your triglyceride levels are in the very high range you are at risk to develop other medical problems, so you will most likely need to take medication.

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Medications For High Triglycerides

Many people who have high cholesterol also have high triglycerides . Some medications can help lower this type of fat directly. Once these levels go down, the total amount of cholesterol is often lowered.

A common prescription for high triglycerides is niacin or vitamin B-3. Niacin can help lower bad cholesterol and increase good cholesterol .

This is a good option for people who dont respond well to other medications because the side effects of niacin are mild. People taking this medication might experience the following:

  • flushing of the face

When more aggressive treatment is necessary to treat high triglycerides, a class of medications called fibrates is often prescribed.

Also, dietary supplements of omega-3 fatty acids found in fish oil have been shown to reduce triglyceride levels.

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